cripple

To cause severe financial damage to a person, company, or economy.

To cause a great amount of damage to a system, organization, or economy.

To cause an irreversible injury leading to disability.

To cause an injury that makes someone disabled for the rest of their life.

To cause severe and lasting psychological or emotional damage to someone.

To be the cause of someone becoming permanently injured or disabled.

To be severely affected by a disease, condition, or negative emotion (e.g., arthritis, debt).