crippling

Refers to a level of debt so large that it is impossible or nearly impossible for the borrower to repay, causing severe financial hardship.

Indicates a consequence or result that severely damages or weakens a system, organization, or person.

A physical injury that is so severe it causes permanent disability or severely impairs movement or function.

Describes a responsibility, duty, or debt that is extremely difficult to manage and severely limits one's freedom or progress.

A work stoppage by employees that causes severe disruption to an industry, company, or public service.

Refers to an event or action that causes severe damage or harm to someone's hopes, plans, or confidence.

A stroke (sudden interruption of blood supply to the brain) that results in severe and permanent loss of function, such as paralysis.

An official ban on trade or other commercial activity with a particular country that causes severe economic harm to it.